Diseño y construcción de una instalación cunícola destinada a la producción de carne en el municipio de Torralbilla (Zaragoza)

El presente trabajo que se plantea consiste en el “Diseño y construcción de una instalación cunícola destinada a la producción de carne en el municipio de Torralbilla (Zaragoza)”. Con la realización de dicho trabajo, se pretende dar solución a una instalación ganadera con capacidad para 600 madres reproductoras, las cuales, mediante un programa reproductivo y unos manejos adecuados, producirán una descendencia anual de 38000 gazapos, cuya finalidad será la comercialización de su carne. La explotación cunícola constará de dos naves de estructura de hormigón, con capacidad para 300 hembras cada una, así como su descendencia y reposición. Ubicaremos en el mismo recinto, una construcción que albergará la zona de cuarentena, almacén, oficina y aseo. Se detallan las diferentes instalaciones con las que contará la explotación para que se produzca un buen rendimiento, así como también se describe un sistema de manejo que nos permitirá rentabilizar las instalaciones. Se ha hecho un presupuesto general para valorar la inversión económica, y a partir de éste, diferentes análisis de sensibilidad para conocer los parámetros que pueden desencadenar la no rentabilidad de las instalaciones

Importancia del Virus del Papiloma Humano y del estado de los márgenes en la evolución de las pacientes sometidas a conización

Objetivos: Hacer un análisis descriptivo de los factores de riesgo que presentaban las pacientes que fueron sometidas a una conización, como opción terapéutica ante una patología cervical. Analizar la evolución a dos años de dichas pacientes, estudiando la relación entre el estado de los márgenes y la persistencia de la infección por el Virus del Papiloma Humano (VPH) y la incidencia de reintervención. Material y métodos: Se ha realizado un estudio descriptivo retrospectivo de las 190 pacientes a las que se les realizó una conización a lo largo del año 2014 en el Servicio de Ginecología del Hospital Universitario Miguel Servet (HUMS) de Zaragoza. Resultados: El 81,1% de las pacientes presentaron lesiones HSIL (High-grade intraepithelial lesión) en la biopsia previa a la conización. Hubo 29 mujeres a las que hubo que reinterveir (15,3%), de ellas, 20 fueron reconizaciones y 9 fueron histerectomías. El 69% de las reintervenciones se realizaron en mujeres con bordes afectos (20 mujeres), mientras que un 13,8% (4 casos) se realizaron sobre bordes no valorables y un 17,2% (5 casos) en mujeres con bordes libres. Todas las pacientes reintervenidas presentaron persistencia de la infección por VPH. Conclusiones: Queda demostrada que la afectación de los bordes de la conización y la persistencia de la infección por el VPH son los principales factores de riesgo para desarrollar una nueva lesión cervical tras la conización y tener que reintervenir a la paciente. Gracias a las estrategias de seguimiento activo actuales se logra disminuir la tasa de infección por el VPH así como la prevalencia de lesiones cervicales potencialmente malignas

Naturalistic driving study for older drivers based on the DriveSafe app

2019 IEEE Intelligent Transportation Systems Conference (ITSC), Auckland, New Zealand, 27-30 Oct. 2019Elderly population is increasing year after year in the developed countries. However, the knowledge of actual mobility needs of senior drivers is scarce. In this paper, we present a naturalistic driving study (NDS) focused on older drivers through smartphone technology and using our DriveSafe app. Our system automatically generates a driving analysis report based on objective indicators. The proposal supposes an improvement over the traditional surveys and observers, and represents an advance over the current NDSs by using smartphones instead of complex instrumented vehicles. Our method avoids the problems of manual annotation by using an automatic method for data reduction information. Furthermore, a comparison between traditional questionnaires and information provided by our system is carried out and conclusions are presented.Ministerio de Economía y CompetitividadDGTComunidad de Madri

High-Performance Sustainable Asphalt Mixtures for High-Volume Tra c Roads in Severe Climates

This paper summarizes the work carried out in a research project whose main objective was to develop high-performance sustainable bituminous materials (using crumb rubber and additives to reduce their manufacturing temperature) to be used in roads that support high tra c volumes and/or severe environmental conditions. For this purpose, various studies were conducted both in a laboratory and in a real asphalt plant (at binder and mixture level). Later, these materials were used to construct a trial section in a highway at a mountain pass (at more than 1400 m above sea level) supporting more than 2600 heavy vehicles each day under severe environmental conditions (snow during winter, and high temperatures and many hours of solar radiation during the summer). The results indicate the viability of using these materials, since they provide a number of advantages such as improved workability at lower temperatures and an increase in the mechanical resistance against the main sources of distress that a ect asphalt pavements

The Experience of Robesafe Team in CARLA Autonomous Driving Challenge

Robótica e Inteligencia Artificial: Retos y nuevas oportunidades. 10 de diciembre de 2019, ETSII UPM (RoboCity2030)The future of the automotive is focused on achieving total autonomous cars in realistic urban environments. To reach it, many researching teams are working with 3D simulators such as V-REP and Gazebo, due to an easy integration with ROS platform. ROS is a middle-ware for robot code development. It allows easy communication between different systems. It is multilanguage, admitting C++ and Python code programming. Those simulators provide precise motion information, but they are designed for smaller environments like robotic arms, providing unrealistic appearance and very slow performance, being unrecommended for real-time systems in rich worlds like urban cities. CARLA simulator provides high detailed environments in realistic urban situations, being able to train and test control and perception algorithms in complex traffic scenarios, very close to real situations. CARLA Autonomous Driving Challenge was launched in Summer 2019, allowing everyone to test their own control techniques under the same traffic scenarios, scoring its performance regarding traffic rules. Robesafe researching group, from Universidad de Alcalá, submitted to this challenge, with the aim of achieving high results and compare our control and perception techniques with others provided by other teams.Comunidad de Madri

Real-Time Bird's Eye View Multi-Object Tracking system based on Fast Encoders for object detection

2020 IEEE 23rd International Conference on Intelligent Transportation Systems (ITSC), September 20-23, 2020, Rhodes, Greece. Virtual Conference.This paper presents a Real-Time Bird’s Eye View Multi Object Tracking (MOT) system pipeline for an Autonomous Electric car, based on Fast Encoders for object detection and a combination of Hungarian algorithm and Bird’s Eye View (BEV) Kalman Filter, respectively used for data association and state estimation. The system is able to analyze 360 degrees around the ego-vehicle as well as estimate the future trajectories of the environment objects, being the essential input for other layers of a self-driving architecture, such as the control or decision-making. First, our system pipeline is described, merging the concepts of online and realtime DATMO (Deteccion and Tracking of Multiple Objects), ROS (Robot Operating System) and Docker to enhance the integration of the proposed MOT system in fully-autonomous driving architectures. Second, the system pipeline is validated using the recently proposed KITTI-3DMOT evaluation tool that demonstrates the full strength of 3D localization and tracking of a MOT system. Finally, a comparison of our proposal with other state-of-the-art approaches is carried out in terms of performance by using the mainstream metrics used on MOT benchmarks and the recently proposed integral MOT metrics, evaluating the performance of the tracking system over all detection thresholds.Ministerio de Ciencia, Innovación y UniversidadesComunidad de Madri

Clinical and demographic factors in endometrial and ovary carcinoma: Synchronous carcinoma vs stage IIIA endometrial carcinoma

Objective: To compare pre-surgical demographic and clinical factors and preoperative serum tumor marker values of patients with endometrial and ovarian synchronous carcinoma with those diagnosed with endometrial carcinoma with metastatic ovarian involvement (FIGO stage IIIA). Methods: A retrospective observational study including patients with endometrial and ovarian malignant tumors that were treated at Miguel Servet University Hospital, Zaragoza, Spain, since January 2000 to June 2020. All pathologic specimens were reviewed by two pathologists specialized in gynecological oncology. Results: Overall, 51 patients were included. 24 cases of them, were endometrial and ovarian synchronous primary carcinomas and the remaining 27 cases were endometrial tumors with adnexa. Parity, personal and family oncological history, arterial hypertension, diabetes, dyslipidemia, obesity and the prior use of hormone replacement therapy did not show significant differences between both groups. Age (p = 0.002), menopausal status (p = 0.029), abnormal uterine bleeding (p = 0.001), Ca 12.5 preoperative serum level (p = 0.038) and Ca 19.9 preoperative serum level (0.028) were factors with significant differences between both groups. In multivariate analysis, only abnormal uterine bleeding and Ca 19.9 values were independents factors. Conclusions: The presence of abnormal uterine bleeding and Ca 19.9 preoperative serum level could guide the clinician in the preoperative differential diagnosis between endometrial cancer with ovarian involvement and endometrial and ovarian synchronous carcinoma. © 2021 The Author(s)

The case of a southern European glacier disappearing under recent warming that survived Roman and Medieval warm periods

Mountain glaciers have generally experienced an accelerated retreat over the last three decades as a rapid response to current global warming. However, the response to previous warm periods in the Holocene is not well-described for glaciers of the of southern Europe mountain ranges, such as the Pyrenees. The situation during the Medieval Climate Anomaly (900-1300 CE) is particularly relevant since it is not certain whether the glaciers just experienced significant ice loss or whether they actually disappeared. We present here the first chronological study of a glacier located in the Central Pyrenees (N Spain), the Monte Perdido Glacier (MPG), carried out by different radiochronological techniques and their comparison with geochemical proxies with neighboring paleoclimate records. The result of the chronological model proves that the glacier endured during the Roman Period and the Medieval Climate Anomaly. The lack of ice from last 600 years indicates that the ice formed during the Little Ice Age has melted away. The analyses of the content of several metals of anthropogenic origin, such as Zn, Se, Cd, Hg, Pb, appear in low amounts in MPG ice, which further supports our age model in which the record from the industrial period is lost. This study confirms the exceptional warming of the last decades in the context of last two millennia. We demonstrate that we are facing an unprecedented retreat of the 55 Pyrenean glaciers which survival is compromised beyond a few decades

Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution

Aging is the main risk factor for cardiovascular diseases. In humans, cardiac aging remains poorly characterized. Most studies are based on chronological age (CA) and disregard biological age (BA), the actual physiological age (result of the aging rate on the organ structure and function), thus yielding potentially imperfect outcomes. Deciphering the molecular basis of ventricular aging, especially by BA, could lead to major progresses in cardiac research. We aim to describe the transcriptome dynamics of the aging left ventricle (LV) in humans according to both CA and BA and characterize the contribution of microRNAs, key transcriptional regulators. BA is measured using two CA-associated transcriptional markers: CDKN2A expression, a cell senescence marker, and apparent age (AppAge), a highly complex transcriptional index. Bioinformatics analysis of 132 LV samples shows that CDKN2A expression and AppAge represent transcriptomic changes better than CA. Both BA markers are biologically validated in relation to an aging phenotype associated with heart dysfunction, the amount of cardiac fibrosis. BA-based analyses uncover depleted cardiac-specific processes, among other relevant functions, that are undetected by CA. Twenty BA-related microRNAs are identified, and two of them highly heart-enriched that are present in plasma. We describe a microRNA-gene regulatory network related to cardiac processes that are partially validated in vitro and in LV samples from living donors. We prove the higher sensitivity of BA over CA to explain transcriptomic changes in the aging myocardium and report novel molecular insights into human LV biological aging. Our results can find application in future therapeutic and biomarker research